Rejection uses the same pathway in the brain as physical pain. Tylanol can help reduce that emotional pain. fMRI studies show that the same areas of the brain become activated when we experience rejection as when we experience physical pain. This is why rejection hurts so much (neurologically speaking) To test the hypothesis that rejection mimics physical pain, scientists gave some people Tylenol (acetaminophen) before asking them to recall a painful rejection experience. Participants who received Tylenol reported significantly less emotional pain than subjects who received a sugar pill. Psychologists assume there is a specific reason for the strong link between rejection and physical pain.